ABSTRACT
OBJECTIVE: Coronavirus disease-19 (COVID-19) primarily affects the respiratory system. In some cases, the heart, kidney, liver, circulatory system, and nervous system are also affected. COVID-19-related acute kidney injury (AKI) occurs in more than 20% of hospitalized patients and more than 50% of patients in the intensive care unit (ICU). In this study, we aimed to review the prevalence of COVID-19-related acute kidney injury, risk factors, hospital and ICU length of stay, the need for renal replacement therapy. We also examined the effect of AKI on mortality in patients in the ICU that we treated during a 1-year period. PATIENTS AND METHODS: The files of patients with COVID-19 (n=220) who were treated in our ICU between March 21st, 2020, and June 1st, 2021, were analyzed retrospectively. Demographic data of the patients, laboratory data, and treatments were examined. Patients were divided into two groups, group I patients without AKI and, group II patients with AKI. The patients with AKI were evaluated according to the theKidney Disease Improving Global Outcomes (KDIGO) classification and were graded. RESULTS: Of the 220 patients included in the study, 89 were female and 131 were male. The mean age of patients with AKI (70.92±11.28 years) was statistically significantly higher than among those without AKI (58.87±13.63 years) (p<0.001). In patients with AKI, ICU length of stay, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, initial lactate levels, need for mechanical ventilation, duration of mechanical ventilation, and secondary infection rates were found to be statistically significantly higher. Discharge rates from the ICU in patients without AKI were statistically higher (75.3% vs. 26.6%), and mortality rates were significantly higher in patients with AKI (67.8% vs. 14.3%). CONCLUSIONS: Various studies conducted have shown that patients with COVID-19 are at risk for AKI, and this is closely related to age, sex, and disease severity. The presence of AKI in patients with COVID-19 increases mortality, and this is more evident in patients hospitalized in the ICU. In our study, the prevalence of AKI was higher in older patients with high APACHE II scores and initial lactate levels. Comorbidities such as hypertension, chronic kidney disease, and coronary artery disease in patients with AKI were higher than in those without AKI.
Subject(s)
Acute Kidney Injury/etiology , COVID-19/complications , Intensive Care Units , APACHE , Acute Kidney Injury/therapy , Age Factors , Aged , Aged, 80 and over , COVID-19/mortality , Cross Infection/complications , Female , Humans , Lactic Acid/blood , Male , Middle Aged , Prevalence , Respiration, Artificial , Retrospective Studies , Sex FactorsABSTRACT
As the COVID-19 pandemic continues to grow in many areas of the world, the virus may increasingly infect military service members and their families. Most service members who contract COVID-19 develop a mild disease course that requires primarily supportive care and steps to limit the spread of infection to others. However, increasing evidence suggests that heart, lung, and coagulation disorders and psychological sequelae may occur even among generally healthy young adult COVID-19 patients. These potential manifestations of the disease are a cause for concern for Israeli Air Force pilot cadets and aircrew personnel, particularly in high-performance aircraft, because they may lead to decreased performance during flight and potentially to sudden incapacitation. In this article, the authors describe the Israeli Aeromedical Center’s recommendations to flight surgeons on the medical workup required before military aviators return to flight duties after recovery from COVID-19. © 2021 Izvestiya of Saratov University. New Series. Series: Mathematics. Mechanics. Informatics. All rights reserved.